The diagnostic value of n-terminal probrain natriuretic peptides to differentiate neonatal pneumoniae and transient tachypnea of the newborn

Background/aim: The primary objective of the study was to determine diagnostic value serum N-terminal probrain natriuretic peptide (NT-proBNP) levels differentiate neonatal pneumonia (NP) and transient tachypnea newborn (TTN). secondary investigate prognostic role NT-proBNP in neonates with severe respiratory distress (RD). Materials methods: A prospective, observational, single-blinded involving 58 late preterm term newborns who were diagnosed TTN or NP conducted between June 2020 2021 at a level-3 intensive care unit Kırıkkale University Faculty Medicine. groups compared for measured 1st 24th hours life. Optimal cut-off determined by Youden index predict diagnosis NP. Lung ultrasound used support In addition, lung score (LUS) RD. Results: median level significantly higher hour life group than group, respectively 7263.5 pg/mL (1643-35,000) 3308 (69-19,746), p = 0.004. At 5515.5 pg/mL, had sensitivity 75% specificity 73.8% [AUC= 0.749 (95% CI: 0.602-0.895; 0.004)]. population divided into two as high (n: 23, LUS < 7) low 35, according 6th values 6320 (69-35,000) 3500 (570-15,948) 0.044. Duration oxygen (p 0.006), noninvasive ventilation 0.008) NICU stay 0.004) high-score group. Conclusion: can be relatively early predictor differentiation neonates. elevated are related which reflects severity RD regardless diagnosis.